New paper highlights how DNA hydroxymethylation in the human brain change during development.

Previous work from our group described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development. Other epigenetic processes operating during this period have not been extensively explored – of particular interest is DNA hydroxymethylation (5hmC), a modification that we have found to be enriched in the human brain, and which is hypothesized […]

Schizophrenia-Associated Methylomic Variation

2017 Software Sustainability Fellows announced

Upcoming Event: Exeter Neuroscience Research Seminar, 6 Sept 2016

Exeter Neuroscience Seminar Series 6 September, 2016 16:00 – 18:00 White Hart Inn, 66 South Street, Exeter, EX1 1EE  Mick Craig  – Using network oscillations to probe neural circuit function  Mick’s main interest is studying the cellular circuitry that enables different regions of the brain synchronise their activity over long distances, with a particular focus on […]

Olivia Knox

Student Success at Human Methylation Array Meeting

Friday the 3rd of June saw a group of students and post-docs from our group attend the 5th annual Human Methylation Array Meeting at King’s College London. PhD student Sarah Marzi was part of the organising committee of this popular meeting designed to bring together members of the scientific community all working with the same […]

Quantifying DNA hydroxymethylation in the human brain

A new paper from our group published in Genome Biology characterizes the distribution of DNA hydroxymethylation (5hmC) in two regions of the human brain. We used oxidative bisulfite (oxBS) treatment with the Illumina Infinium 450K BeadArray to quantify genome-wide patterns of 5hmC in the prefrontal cortex and cerebellum. Distinct patterns of 5hmC were identified in […]

Methylation QTLs (mQTLs) in the developing brain and their enrichment in schizophrenia-associated genomic regions

Our study looking at genetic influences on DNA methylation in the developing human brain was published online today in Nature Neuroscience. The study, led by Dr Eilis Hannon, identified >16,000 fetal brain mQTLs which were primarily cis-acting, enriched in regulatory chromatin domains and transcription factor binding sites, and showed substantial overlap with genetic variants that […]

ESRC and BBSRC grant for epigenetic research on early life experiences and long term health

Dr Chloe Wong has received funding and is the Principal Investigator for a project entitled ‘Epigenetic trajectories of biological response to adolescent psychosocial stress: A novel longitudinal study of discordant monozygotic twins.’ This is one of eight projects, funded by the ESRC and the BBSRC, which combines biological and social sciences to uncover the long […]

Long reads, single cells and cream teas

To celebrate the launch of our new Pacific Biosciences sequencer, funded by the MRC Clinical Research Infrastructure scheme, we’d like to invite you to a special one-day meeting. It will be held in at the RILD building in Exeter on the 1st September 2015. We have a great line-up of international speakers. Click here for […]

Alzheimer’s Society grant to integrate genetic and epigenetic findings

Katie Lunnon has led a successful application to the Alzheimer’s Society to fund a project building on our previous studies of DNA methylation in Alzheimer’s disease brain. The project will aim to combine data from multiple studies across the world, and integrate findings with genetic data on the same patients.

Twin birth cohort recruits its first participants

The first set of twins who will be part of the new Peninsula Pre/Perinatal Twins Research Bank (PTRB) have been born. The PTRB has been established to enable us to study how growth in the womb can influence health and disease across the life-course. For more information, go to the PTRB page.

Student led Alzheimer’s project grants get seal of approval.

Pilot research awards have been awarded to PhD researchers Matt and Adam respectively by the recently established Alzheimer’s Research UK (ARUK) Southwest Network. Both studies aim to improve our current understanding of the dynamic epigenetic landscape and its association with the onset and progression of Alzheimer’s pathology. Matt’s grant will focus on the expression of […]

GW4 accelerator award: Harnessing CRISPR/Cas9 technology to develop new models of Alzheimer’s disease

In collaboration with Nick Allen at the University of Cardiff, Vasanta Subramanian at the University of Bath, and James Hodge and Caroline Relton at the University of Bristol we have been awarded a GW4 accelerator award to investigate the functional consequences of epigenetic changes previously identified in Alzheimer’s disease brain by our group. Together we […]

Pacific Biosciences sequencer delivered!

Our Pacific Biosciences RSII sequencer was delivered today. This was funded by a MRC Clinical Research Infrastructure Award. It was quite a big box! We can’t wait to get going on long-read sequencing and exploring the possibilities for human clinical genomics.

Our paper on DNA methylation trajectories across human brain development published in Genome Research

  Our study tracking changes in DNA methylation across human brain development has been published today in Genome Research. The study was led by PhD student Helen Spiers, and examined genome-wide patterns of DNA methylation in 179 human fetal brain samples (100 male, 79 female) spanning 23 to 184 days post-conception. In addition, we have […]