Publications

Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease.

Harvey J, Reijnders RA, Cavill R, Duits A, Köhler S, Eijssen L, Rutten BPF, Shireby G, Torkamani A, Creese B, Leentjens AFG, Lunnon K, Pishva E. NPJ Parkinsons Dis. 2022 Nov 7;8(1):150. doi: 10.1038/s41531-022-00409-5. PMID: 36344548.

Neuropsychiatric symptoms in AD: the search for mechanisms.

Creese B, Lunnon K. Nat Rev Neurol. 2022 Nov;18(11):639-640. doi: 10.1038/s41582-022-00721-x. PMID: 36114241.

Cortical neuronal hyperexcitability and synaptic changes in SGCE mutation-positive myoclonus dystonia

Sperandeo A, Tamburini C, Noakes Z, de la Fuente DC, Keefe F, Petter O, Plumbly W, Clifton N, Li M, Peall K.  Brain. 2022 Oct 7:awac365. doi: 10.1093/brain/awac365.

DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

Shireby G, Dempster EL, Policicchio S, Smith RG, Pishva E, Chioza B, Davies JP, Burrage J, Lunnon K, Seiler Vellame D, Love S, Thomas A, Brookes K, Morgan K, Francis P, Hannon E, Mill J. Nat Commun. 2022 Sep 24;13(1):5620. doi: 10.1038/s41467-022-33394-7.

Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function

Clifton NE, Bosworth ML, Haan N, Rees E, Holmans PA, Wilkinson LS, Isles AR, Collins MO, Hall J. Hum Mol Genet. 2022 Sep 10;31(18):3095-3106. doi: 10.1093/hmg/ddac105.

Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays

Flynn R, Washer S, Jeffries AR, Andrayas A, Shireby G, Kumari M, Schalkwyk LC, Mill J, Hannon E. Hum Mol Genet. 2022 Sep 10;31(18):3181-3190. doi: 10.1093/hmg/ddac112.

Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing

Leung SK, Jeffries AR, Castanho I, Jordan BT, Moore K, Davies JP, Dempster EL, Bray NJ, O’Neill P, Tseng E, Ahmed Z, Collier DA, Jeffery ED, Prabhakar S, Schalkwyk L, Jops C, Gandal MJ, Sheynkman GM, Hannon E, Mill J.  Cell Rep. 2021 Nov 16;37(7):110022. doi: 10.1016/j.celrep.2021.110022.

Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity

Clifton NE, Collado-Torres L, Burke EE, Pardiñas AF, Harwood JC, Di Florio A, Walters JTR, Owen MJ, O’Donovan MC, Weinberger DR, Holmans PA, Jaffe AE, Hall J.  Biol Psychiatry. 2021 Sep 15;90(6):399-408. doi: 10.1016/j.biopsych.2021.03.009.

Genetic association of FMRP targets with psychiatric disorders

Clifton NE, Rees E, Holmans PA, Pardiñas AF, Harwood JC, Di Florio A, Kirov G, Walters JTR, O’Donovan MC, Owen MJ, Hall J, Pocklington AJ. Mol Psychiatry. 2021 Jul;26(7):2977-2990. doi: 10.1038/s41380-020-00912-2.

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons

Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, Neilson GWA, Walker EM, Perfect LW, Price J, McAlonan G, Srivastava DP, Bray NJ, Cope EL, Jones KM, Allen ND, Pishva E, Dempster EL, Lunnon K, Mill J, Hannon E. Mol Brain. 2021 Jun 26;14(1):98. doi: 10.1186/s13041-021-00810-w.

Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation

Seiler Vellame D, Castanho I, Dahir A, Mill J, Hannon E. BMC Genomics. 2021 Jun 15;22(1):446. doi: 10.1186/s12864-021-07721-z.

A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, Giese A, Sharp AJ, Schalkwyk L, Haroutunian V, Viechtbauer W, van den Hove DLA, Weedon M, Brokaw D, Francis PT, Thomas AJ, Love S, Morgan K, Walter J, Coleman PD, Bennett DA, De Jager PL, Mill J, Lunnon K.  Nat Commun. 2021 Jun 10;12(1):3517. doi: 10.1038/s41467-021-23243-4.

Attenuated Induction of the Unfolded Protein Response in Adult Human Primary Astrocytes in Response to Recurrent Low Glucose

Weightman Potter PG, Washer SJ, Jeffries AR, Holley JE, Gutowski NJ, Dempster EL, Beall C. Front Endocrinol (Lausanne). 2021 May 26;12:671724. doi: 10.3389/fendo.2021.671724.

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

Nabais MF, Laws SM, Lin T, Vallerga CL, Armstrong NJ, Blair IP, Kwok JB, Mather KA, Mellick GD, Sachdev PS, Wallace L, Henders AK, Zwamborn RAJ, Hop PJ, Lunnon K, Pishva E, Roubroeks JAY, Soininen H, Tsolaki M, Mecocci P, Lovestone S, Kłoszewska I, Vellas B; Australian Imaging Biomarkers and Lifestyle study; Alzheimer’s Disease Neuroimaging Initiative, Furlong S, Garton FC, Henderson RD, Mathers S, McCombe PA, Needham M, Ngo ST, Nicholson G, Pamphlett R, Rowe DB, Steyn FJ, Williams KL, Anderson TJ, Bentley SR, Dalrymple-Alford J, Fowder J, Gratten J, Halliday G, Hickie IB, Kennedy M, Lewis SJG, Montgomery GW, Pearson J, Pitcher TL, Silburn P, Zhang F, Visscher PM, Yang J, Stevenson AJ, Hillary RF, Marioni RE, Harris SE, Deary IJ, Jones AR, Shatunov A, Iacoangeli A, van Rheenen W, van den Berg LH, Shaw PJ, Shaw CE, Morrison KE, Al-Chalabi A, Veldink JH, Hannon E, Mill J, Wray NR, McRae AF.  Genome Biol. 2021 Mar 26;22(1):90. doi: 10.1186/s13059-021-02275-5.

Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology

Hannon E, Mansell G, Walker E, Nabais MF, Burrage J, Kepa A, Best-Lane J, Rose A, Heck S, Moffitt TE, Caspi A, Arseneault L, Mill J.  PLoS Genet. 2021 Mar 19;17(3):e1009443. doi: 10.1371/journal.pgen.1009443.

DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forti M, Dinan TG, Donohoe G, Gaughran F, Gill M, Gillespie A, Gunasinghe C, Hulshoff HE, Hultman CM, Johansson V, Kahn RS, Kaprio J, Kenis G, Kowalec K, MacCabe J, McDonald C, McQuillin A, Morris DW, Murphy KC, Mustard CJ, Nenadic I, O’Donovan MC, Quattrone D, Richards AL, Rutten BP, St Clair D, Therman S, Toulopoulou T, Van Os J, Waddington JL; Wellcome Trust Case Control Consortium (WTCCC); CRESTAR consortium, Sullivan P, Vassos E, Breen G, Collier DA, Murray RM, Schalkwyk LS, Mill J. Elife. 2021 Feb 26;10:e58430. doi: 10.7554/eLife.58430.

Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis.

Nabais, M. F., Lin, T., Benyamin, B., Williams, K. L., Garton, F. C., Vinkhuyzen, A. A. E., Zhang, F., Vallerga, C. L., Restuadi, R., Freydenzon, A., Zwamborn, R. A. J., Hop, P. J., Robinson, M. R., Gratten, J., Visscher, P. M., Hannon, E., Mill, J., Brown, M. A., Laing, N. G., Mather, K. A., Sachdev, P. S., Ngo, S. T., Steyn, F. J., Wallace, L., Henders, A. K., Needham, M., Veldink, J. H., Mathers, S., Nicholson, G., Rowe, D. B., Henderson, R. D., McCombe, P. A., Pamphlett, R., Yang, J., Blair, I. P., McRae, A. F. & Wray, N. R. 2020. NPJ Genom Med, 5, 10. doi.org/10.1038/s41525-020-0118-3

Major surgery induces acute changes in measured DNA methylation associated with immune response pathways.

Sadahiro, R., Knight, B., James, F., Hannon, E., Charity, J., Daniels, I. R., Burrage, J., Knox, O., Crawford, B., Smart, N. J. & Mill, J. 2020. Sci Rep, 10, 5743.doi.org/10.1038/s41598-020-62262-x

Genome-Wide DNA Methylation Patterns in Persistent Attention-Deficit/Hyperactivity Disorder and in Association With Impulsive and Callous Traits.

Meijer M, Klein M, Hannon E, van der Meer D, Hartman C, Oosterlaan J, Heslenfeld D, Hoekstra PJ, Buitelaar J, Mill J, Franke B. (2020). Front Genet. doi: 10.3389/fgene.2020.00016

Genome-wide DNA methylation meta-analysis in the brains of suicide completers.

Policicchio S, Washer S, Viana J, Iatrou A, Burrage J, Hannon E, Turecki G, Kaminsky Z, Mill J, Dempster EL, Murphy TM. (2020).Transl Psychiatry. DOI: 10.1038/s41398-020-0752-7

Large epigenome-wide association study of childhood ADHD identifies peripheral DNA methylation associated with disease and polygenic risk burden.

Mooney MA, Ryabinin P, Wilmot B, Bhatt P, Mill J, Nigg JT. (2020).Transl Psychiatry. DOI: 10.1038/s41398-020-0710-4

Transcriptional Signatures of Tau and Amyloid Neuropathology.

Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, Moore K, O’Neill P, Lunnon K, Collier DA, Ahmed Z, O’Neill MJ, Mill J. (2020). Cell Rep. DOI: 10.1016/j.celrep.2020.01.063

Clozapine-induced transcriptional changes in the zebrafish brain.

Viana J, Wildman N, Hannon E, Farbos A, Neill PO, Moore K, van Aerle R, Paull G, Santos E, Mill J. (2020). NPJ Schizophr. DOI: 10.1038/s41537-019-0092-x

Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex.

Pishva E, Creese B, Smith AR, Viechtbauer W, Proitsi P, van den Hove DLA, Ballard C, Mill J, Lunnon K. (2020). Neurobiol Aging. DOI: 10.1016/j.neurobiolaging.2020.01.001

Systematic underestimation of the epigenetic clock and age acceleration in older subjects.

El Khoury LY, Gorrie-Stone T, Smart M, Hughes A, Bao Y, Andrayas A, Burrage J, Hannon E, Kumari M, Mill J, Schalkwyk LC. (2019). Genome Biol. DOI: 10.1186/s13059-019-1810-4

Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood.

Lardenoije R, Roubroeks JAY, Pishva E, Leber M, Wagner H, Iatrou A, Smith AR, Smith RG, Eijssen LMT, Kleineidam L, Kawalia A, Hoffmann P, Luck T, Riedel-Heller S, Jessen F, Maier W, Wagner M, Hurlemann R, Kenis G, Ali M, Del Sol A, Mastroeni D, Delvaux E, Coleman PD, Mill J, Rutten BPF, Lunnon K, Ramirez A, van den Hove DLA. (2019). Clin Epigenetics. DOI: 10.1186/s13148-019-0755-5

RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation.

Saffari A, Arno M, Nasser E, Ronald A, Wong CCY, Schalkwyk LC, Mill J, Dudbridge F, Meaburn EL. (2019). Mol Autism. DOI: 10.1186/s13229-019-0285-1

Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue.

Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W, Prabhakar S, Geschwind DH, Mill J. (2019). Hum Mol Genet. DOI: 10.1093/hmg/ddz052

Methylation age acceleration does not predict mortality in schizophrenia.

Kowalec K, Hannon E, Mansell G, Burrage J, Ori APS, Ophoff RA, Mill J, Sullivan PF. (2019). Transl. Psychiatry. 9(1):157. DOI: 10.1038/s41398-019-0489-3

Association of Lifestyle and Genetic Risk With Incidence of Dementia.

Lourida I, Hannon E, Littlejohns TJ, Langa KM, Hyppönen E, Kuzma E, Llewellyn DJ. (2019). JAMA. DOI: 10.1001/jama.2019.9879

Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults.

van Dongen J, Zilhão NR, Sugden K, Hannon EJ, Mill J, Caspi A, Agnew-Blais J, Arseneault L, Corcoran DL, Moffitt TE et al. (2019). Biol Psychiatry. DOI: 10.1016/j.biopsych.2019.02.016

Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits.

Massrali A, Brunel H, Hannon E, Wong C; iPSYCH-MINERvA Epigenetics Group, Baron-Cohen S, Warrier V. (2019). Mol Autism. DOI: 10.1186/s13229-019-0279-z

Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue.

Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W et al. (2019). Hum Mol Genet 2019, 28(13):2201-2211. DOI: 10.1093/hmg/ddz052

Independent Methylome-Wide Association Studies of Schizophrenia Detect Consistent Case-Control Differences.

Chan RF, Shabalin AA, Montano C, Hannon E, Hultman CM, Fallin MD, Feinberg AP, Mill J, van den Oord EJCG, Aberg KA. (2019). Schizophr Bull. DOI: 10.1093/schbul/sbz056

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease.

Smith AR, Smith RG, Pishva E, Hannon E, Roubroeks JAY, Burrage J, Troakes C, Al-Sarraj S, Sloan C, Mill J, van den Hove DL, Lunnon K. (2019). Clinical Epigenetics 11(1): 52. DOI: 10.1186/s13148-019-0636-y

Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array.

Mansell G, Gorrie-Stone TJ, Bao Y, Kumari M, Schalkwyk LS, Mill J, Hannon E4. (2019). BMC Genomics 20(1): 366. DOI: doi: 10.1186/s12864-019-5761-7

Bigmelon: tools for analysing large DNA methylation datasets.

Gorrie-Stone TJ, Smart MC, Saffari A, Malki K, Hannon E, Burrage J, Mill J, Kumari M, Schalkwyk LC. (2019). Bioinformatics. DOI: 10.1093/bioinformatics/bty713

Dynamic expression of genes associated with schizophrenia and bipolar disorder across development.

Clifton NE, Hannon E, Harwood JC, Di Florio A, Thomas KL1 Holmans PA, Walters JTR, O’Donovan MC, Owen MJ, Pocklington AJ, Hall J. (2019). Transl. Psychiatry. DOI: 10.1038/s41398-019-0405-x

Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight.

Hannon E, Schendel D, Ladd-Acosta C, Grove J, Hansen CS, Hougaard DM, Bresnahan M, Mors O, Hollegaard MV, Bækvad-Hansen M, Hornig M, Mortensen PB, Børglum AD, Werge T, Pedersen MG, Nordentoft M, iPSYCH-Broad ASD Group, Buxbaum JD, Fallin MD, Bybjerg-Grauholm J, Reichenberg A, Mill J. (2019). Phil. Trans. R. Soc. B. DOI: 10.1098/rstb.2018.0120

Establishing a generalized polyepigenetic biomarker for tobacco smoking.

Sugden K, Hannon EJ, Arseneault L, Belsky DW, Broadbent JM, Corcoran DL, Hancox RJ, Houts RM, Moffitt TE, Poulton R, Prinz JA, Thomson WM, Williams BS, Wong CCY, Mill J, Caspi A. (2019). Transl. Psychiatry. DOI: 10.1038/s41398-019-0430-9

Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila.

Higham JP, Malik BR, Buhl E, Dawson JM, Ogier AS, Lunnon K, Hodge JJL.(2019). Front Cell Neurosci. DOI: 10.3389/fncel.2019.00260

A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases.

Smith AR, Smith RG, Burrage J, Troakes C, Al-Sarraj S, Kalaria RN, Sloan C, Robinson AC, Mill J, Lunnon K. (2019). Neurobiol. Aging. DOI: 10.1016/j.neurobiolaging.2018.09.024

Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences.

Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Mill J, Relton C, Arseneault L, Wong CCY, Fisher HL. (2019). Transl. Psychiatry. DOI: 10.1038/s41398-019-0407-8

Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains.

Hannon E, Marzi SJ, Schalkwyk LS, Mill J. (2019). Mol. Brain. DOI: 10.1186/s13041-019-0429-4

Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders.

Heath E. O’Brien, Eilis Hannon, Matthew J. Hill, Carolina C. Toste, Matthew J. Robertson, Joanne E. Morgan, Gemma McLaughlin, Cathryn M. Lewis, Leonard C. Schalkwyk, Lynsey S. Hall, Antonio F. Pardiñas, Michael J. Owen, Michael C. O’Donovan, Jonathan Mill and Nicholas J. Bray. (2018). Genome Biology. DOI: 10.1186/s13059-018-1567-1

Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits.

Eilis Hannon, Tyler J. Gorrie-Stone, Melissa C. Smart, Joe Burrage, Amanda Hughes, Yanchun Bao, Meena Kumari, Leonard C. Schalkwyk, and Jonathan Mill. (2018). The American Journal of Human Genetics. DOI: 10.1016/j.ajhg.2018.09.007

A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex.

Sarah J. Marzi, Szi Kay Leung, Teodora Ribarska, Eilis Hannon, Adam R. Smith , Ehsan Pishva, Jeremie Poschmann, Karen Moore, Claire Troakes , Safa Al-Sarraj, Stephan Beck , Stuart Newman, Katie Lunnon, Leonard C. Schalkwyk and Jonathan Mill . (2018).  Nature Neuroscience. DOI: 10.1038/s41593-018-0253-7

Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion.

Clissold, RL., Ashfield, B., Burrage. J., Hannon, E., Bingham, C., Hattersley, A., Dempster EL. (2018). Clin Epigenetics. DOI: 10.1186/s13148-018-0530-z

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. 

Luijk, R., Wu, H., Ward-Caviness, C. K., Hannon, E., Carnero-Montoro, E., Min, J. L., Mandaviya, P., Müller-Nurasyid, M., Mei, H., van der Maarel, S. M., Relton, C., Mill, J., Waldenberger, M., Bell, J. T., Jansen, R., Zhernakova, A., Franke, L., ‘t Hoen, P. A. C., Boomsma, D. I., van Duijn, C. M., van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., van Meurs, J., Daxinger, L., Slagboom, P. E., van Zwet, E. W., Heijmans, B. T. & Consortium, B. (2018). Nat Commun. DOI: 10.1038/s41467-018-05714-3

Bigmelon: Tools for analysing large DNA methylation datasets.

Gorrie-Stone, T. J., Smart, M. C., Saffari, A., Malki, K., Hannon, E., Burrage, J., Mill, J., Kumari, M. & Schalkwyk, L. C. (2018). Bioinformatics. DOI: 10.1093/bioinformatics/bty713

Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. 

Hannon, E., Knox, O., Sugden, K., Burrage, J., Wong, C. C. Y., Belsky, D. W., Corcoran, D. L., Arseneault, L., Moffitt, T. E., Caspi, A. & Mill, J. (2018a). PLoS Genet 14. DOI: 10.1371/journal.pgen.1007544

Socioeconomic Position and DNA Methylation Age Acceleration across the Lifecourse.

Hughes, A., Smart, M., Gorrie-Stone, T., Hannon, E., Mill, J., Bao, Y., Burrage, J., Schalkwyk, L. & Kumari, M. (2018). Am J Epidemiol. DOI: 10.1093/aje/kwy155

Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies.

Kuźma, E., Hannon, E., Zhou, A., Lourida, I., Bethel, A., Levine, D. A., Lunnon, K., Thompson-Coon, J., Hyppönen, E. & Llewellyn, D. J. (2018). J Alzheimers Dis. DOI: 10.3233/JAD-18001

DNA methylation and inflammation marker profiles associated with a history of depression.

Crawford B, Craig Z, Mansell G, White I, Smith A, Spaull S, Imm J, Hannon E, Wood A, Yaghootkar H, Ji Y, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Mullins N, Lewis CM, Mill J, Murphy TM. (2018). Human Molecular Genetics. DOI: 10.1093/hmg/ddy199

Hannon E, Schendel D, Ladd-Acosta C, Grove J; iPSYCH-Broad ASD Group, Hansen CS, Andrews SV, Hougaard DM, Bresnahan M, Mors O, Hollegaard MV, Bækvad-Hansen M, Hornig M, Mortensen PB, Børglum AD, Werge T, Pedersen MG, Nordentoft M, Buxbaum J, Daniele Fallin M, Bybjerg-Grauholm J, Reichenberg A, Mill J. (2018). Elevated polygenic burden for autism is associated with differential DNA methylation at birth. Genome Medicine. DOI: 10.1186/s13073-018-0527-4

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer’s disease neuropathology.

Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, Bennett DA, Powell J, Lovestone S, Schalkwyk L, Mill J, Lunnon K. (2018).  Alzheimer’s & Dementia. DOI: 10.1016/j.jalz.2018.01.017

CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus.

Nelissen TP, Bamford RA, Tochitani S, Akkus K, Kudzinskas A, Yokoi K, Okamoto H, Yamamoto Y, Burbach JPH, Matsuzaki H, Oguro-Ando A. (2018). Neuroscience. DOI: 10.1016/j.neuroscience.2017.12.050

Meta-analysis of epigenome-wide association studies of cognitive abilities.

Marioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai PC, Vojinovic D, Simino J, Levy D, Liu C, Mendelson M , Satizabal CL, Yang Q, Jhun MA, Kardia SLR, Zhao W, Bandinelli S, Ferrucci L, Hernandez DG, Singleton AB, Harris SE, Starr JM, Kiel DP, McLean RR, Just AC, Schwartz J, Spiro A, Vokonas P, Amin N, Ikram MA, Uitterlinden AG, van Meurs JBJ, Spector TD, Steves C, Baccarelli AA, Bell JT, van Duijn CM, Fornage M, Hsu YH , Mill J, Mosley TH20,42, Seshadri S, Deary IJ. (2018). Mol Psychiatry. DOI: 10.1038/s41380-017-0008-y

Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood

Marzi SJ, Sugden K, Arseneault L, Belsky DW, Burrage J, Corcoran DL, Danese A, Fisher HL, Hannon E, Moffitt TE, Odgers CL, Pariante C, Poulton R, Williams BS, Wong CCY, Mill J, Caspi A (2018). Am J Psychiatry. DOI: 10.1176/appi.ajp.2017.17060693

5-hydroxymethylcytosine is highly dynamic across human fetal brain development.

Spiers H, Hannon E, Schalkwyk L, Bray N, & Mill J. BMC Genomics. 2017 September. 18:738; doi:10.1186/s12864-017-4091-x

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.

Lu, A. T., Hannon, E., Levine, M. E., Crimmins, E. M., Lunnon, K., Mill, J., Geschwind, D. H. & Horvath, S. (2017). Nat Commun 8, 15353.

Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci.

Hannon, E., Weedon, M., Bray, N., O’Donovan, M. & Mill, J. (2017). Am J Hum Genet.

Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide.

T M Murphy, B Crawford1, E L Dempster, E Hannon, J Burrage, G Turecki, Z Kaminsky and J Mill. Translational Psychiatry. 2017 Jan. 7, e989; doi:10.1038/tp.2016.249

ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity.

Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD. PLoS One. 2017 Jul 12;12(7):e0177814. doi: 10.1371/journal.pone.0177814.

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder.

Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, Kenis G, Viechtbauer W, van den Hove D, Schraut KG, Lesch KP, Kleinman JE, Hyde TM, Weinberger DR, Schalkwyk L, Lunnon K, Mill J, Cohen H, Yehuda R, Baker DG, Maihofer AX, Nievergelt CM, Geuze E, Boks MPM. Mol Psychiatry. 2017 Jun 20. doi: 10.1038/mp.2017.120.

Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. 

Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K. Clin Epigenetics. 2017 May 3;9:47.

Paternal Age Alters Social Development in Offspring.

Janecka M, Haworth CMA, Ronald A, Krapohl E, Happé F, Mill J, Schalkwyk LC, Fernandes C, Reichenberg A, Rijsdijk F. J Am Acad Child Adolesc Psychiatry. 2017 May;56(5):383-390.

Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study.

Walton E, Pingault JB, Cecil CA, Gaunt TR, Relton CL, Mill J, Barker ED. Mol Psychiatry. 2017 Feb;22(2):250-256.

Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms.

Janecka M, Mill J, Basson MA, Goriely A, Spiers H, Reichenberg A, Schalkwyk L, Fernandes C. Transl Psychiatry. 2017 Jan 31;7(1):e1019.

Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review.

Gillespie AL, Samanaite R, Mill J, Egerton A, MacCabe JH. BMC Psychiatry. 2017 Jan 13;17(1):12.

Profiling Regulatory Variation in the Brain: Methods for Exploring the Neuronal Epigenome.

Jeffries AR, Mill J. Biol Psychiatry. 2017 Jan 15;81(2):90-91.

Rapid Down-Regulation of Glucocorticoid Receptor Gene Expression in the Dentate Gyrus after Acute Stress in vivo: Role of DNA Methylation and MicroRNA Activity.

Mifsud KR, Saunderson EA, Spiers H, Carter SD, Trollope AF, Mill J, Reul JM. Neuroendocrinology. 2017;104(2):157-169.

Schizophrenia-associated methylomic variation: molecular signatures of disease and polgenic risk burden across multiple brain regions.

Joana Viana; Eilis Hannon; Emma Dempster; Ruth Pidsley; Ruby Macdonald; Olivia Knox; Helen Spiers; Claire Troakes; Safa Al-Saraj; Gustavo Turecki; Leonard C Schalkwyk; Jonathan Mill. Hum Mol Genet. December 2016. DOI: 10.1093/hmg/ddw373

Genetic Variation at 16q24.2 is associated with small vessel stroke. Ann Neurol..

Traylor, M., Malik, R., Nalls, M. A., Cotlarciuc, I., Radmanesh, F., Thorleifsson, G., Hanscombe, K. B., Langefeld, C., Saleheen, D., Rost, N. S., Yet, I., Spector, T. D., Bell, J. T., Hannon, E., Mill, J., Chauhan, G., Debette, S., Bis, J. C., Longstreth, W. T., Ikram, M. A., Launer, L. J., Seshadri, S., Jimenez-Conde, J., Cole, J. W., Schmidt, R., Słowik, A., Lemmens, R., Lindgren, A., Melander, O., Grewal, R. P., Sacco, R. L., Rundek, T., Rexrode, K., Arnett, D. K., Johnson, J. A., Benavente, O. R., Wasssertheil-Smoller, S., Lee, J. M., Pulit, S. L., Wong, Q., Rich, S. S., de Bakker, P. I., McArdle, P. F., Woo, D., Anderson, C. D., Xu, H., Heitsch, L., Fornage, M., Jern, C., Stefansson, K., Thorsteinsdottir, U., Gretarsdottir, S., Lewis, C. M., Sharma, P., Sudlow, C. L., Rothwell, P. M., Boncoraglio, G. B., Thijs, V., Levi, C., Meschia, J. F., Rosand, J., Kittner, S. J., Mitchell, B. D., Dichgans, M., Worrall, B. B., Markus, H. S., METASTROKE, U. K. Y. L. D. S., N. I. N.DS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium, M.nica Anne Hamilton-Bruce & Consortium, I. S. G. (2016).

Collapsed methylation quantitative trait loci analysis for low frequency and rare variants.

Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, Ring SM, Rodriguez S, Campbell C, Smith GD, Relton CL, Timpson NJ, Gaunt TR. Hum Mol Genet. Published ahead of print 2016 August. doi:10.1093/hmg/ddw283

 An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. 

Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, Kaprio J, Toulopoulou T, Hulshoff Pol HE, Bohlken MM, Kahn RS, Nenadic I, Hultman CM, Murray RM, Collier DA, Bass N, Gurling H, McQuillin A, Schalkwyk L, Mill J. Genome Biology. 2016 17:176. doi:10.1186/s13059-016-1041-x

Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming.

Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J. RNA Published ahead of print  August 18, 2016. doi:10.1261/rna.058347.116

 Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans.

Houtepen LC, Vinkers CH, Carrillo-Roa T, Hiemstra M, van Lier PA, Meeus W, Branje S, Heim CM, Nemeroff CB, Mill J, Schalkwyk LC, Creyghton MP, Kahn RS, Joëls M, Binder EB, Boks MP. Nat Commun. 2016 Mar. 7:10967. doi:10.1038/ncomms10967

An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication. 

Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RC, Roza SJ, Jaddoe VW, Verhulst FC, Felix JF, Cecil CA, Relton CL, Gaunt TR, McArdle W, Mill J, Barker ED, Tiemeier H, van IJzendoorn MH. Epigenetics. 2016 Feb. 11(2):140-9. doi:10.1080/15592294.2016.1145329.

Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus.

Saundersona EA, Spiers H, Mifsuda KR, Gutierrez-Mecinasa M, Trollopea AF, Shaikha A, Mill J, Reula JMHM. 2016.  PNAS. Published ahead of print April 12. doi:10.1073/pnas.1524857113

Variation in 5-hydroxymethylcytosine across human cortex and cerebellum.

Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, Mill J. 2016 Feb.  Genome Biol. 17(1):27. doi: 10.1186/s13059-016-0871-x. PMID: 26883014

Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model.

Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J.  2016 Feb. Mech Ageing Dev. pii: S0047-6374(16)30006-9. doi: 10.1016/j.mad.2016.02.001. [Epub ahead of print]. PMID: 26861500

Tissue-specific patterns of allelically-skewed DNA methylation. 

Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J. 2016 Jan. Epigenetics. 19:1-12. PMID: 26786711

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum.

Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S. 2016.  Nat Commun. 7: 10561.

DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence.

Cecil CA, Walton E, Smith RG, Viding E, McCrory EJ, Relton CL, Suderman M, Pingault JB, McArdle W, Gaunt TR, Mill J, Barker ED. Transl Psychiatry. 2016 Dec 6;6(12):e976.

Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability.

Cecil CA, Smith RG, Walton E, Mill J, McCrory EJ, Viding E. J Psychiatry Res. 2016 Dec;83:184-194.

Histone Acetylome-wide Association Study of Autism Spectrum Disorder.

Sun W, Poschmann J, Cruz-Herrera Del Rosario R, Parikshak NN, Hajan HS, Kumar V, Ramasamy R, Belgard TG, Elanggovan B, Wong CC, Mill J, Geschwind DH, Prabhakar S. Cell. 2016 Nov 17;167(5):1385-1397

Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer’s disease brain.

Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K. Neurobiol Aging. 2016 Nov;47:35-40.

Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection.

Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW.  Sci Rep. 2016 Aug 3;6:30861

Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio).

Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, Santos EM. Epigenetics. 2016 Jul 2;11(7):526-38.

An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication.

Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RC, Roza SJ, Jaddoe VW, Verhulst FC, Felix JF, Cecil CA, Relton CL, Gaunt TR, McArdle W, Mill J, Barker ED, Tiemeier H, van IJzendoorn MH. Epigenetics. 2016;11(2):140-9.

Multigene Methylation Biomarker Analysis in Prostate Cancer.

Murphy TM, Tuzova AV, O’Rourke CJ, O’Meachair  S, Greene C, Sullivan L, Thornhill J, Barrett C, Loftus B, Lynch T, Perry AS. 2015.  Epigenetic Diagnosis & Therapy. 1: 19-27.

Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins.

Murphy TM, Wong CYC, Burrage J, Macdonald R, Moffitt T, Arseneault L, Caspi A, Mill J. 2015. Clinical Epigenetics. 18;7:130.

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. 

Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G,  O’Donovan MC, Schalkwyk LC, Bray NJ, Mill J. 2015. Nature Neuroscience. [Epub ahead of print] DOI:10.1038/nn.4182.

Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. 

Fisher HL*, Murphy TM*, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, Wong CC, Pariante CM, Mill J. 2015. Epigenetics. [Epub ahead of print] DOI:10.1080/15592294.2015.1099797 (*joint first authors)

 A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer’s Disease Diagnosis. 

Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Hodges A, Kiddle S,Dobson RJ. 2015. Journal of Alzheimer’s Disease. [Epub ahead of print] DOI: 10.3233/JAD-150440.

Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. 

Hannon E, Lunnon K, Schalkwyk L, Mill J. 2015. Epigenetics. [Epub ahead of print]

DNA methylation profiling in inflammatory bowel disease provides new insights into disease pathogenesis.

McDermott E, Ryan EJ, Tosetto M, Gibson D, Burrage J, Keegan D, Byrne K, Crowe E, Sexton G, Malone K, Harris RA, Kellermayer R, Mill J,Cullen G, Doherty GA, Mulcahy H, Murphy TM. 2015.  Journal of Crohn’s & Colitis. [Epub ahead of print] DOI: http://dx.doi.org/10.1093/ecco-jcc/jjv176.

A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue-applications for studies of mitochondrial genetics in brain disorders. 

Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K. 2015. Biotechniques. 59(4):241-6.

No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer’s Disease.

Chiam JT, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M,Vellas B, Hodges A, Lovestone S, Newhouse S, Dobson RJ, Kiddle SJ, Sattlecker M. 2015. Journal of Alzheimer’s Disease. 47(3):741-50.

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status.

Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJ, Lannfelt L, Kraus WE, Atherton PJ, Howard R, Gustafsson T, Hodges A, Timmons JA. 2015.  Genome Biol. 16:185.

A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation.

Hannon E, Chand AN, Evans MD, Wong CC, Grubb MS, Mill J. 2015.  Neuroepigenetics 3:1-6.

Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes.

Murphy TM, O’Donovan A, Mullins N, O’Farrelly C, McCann A, Malone K. 2015.  Psychiatric Genetics. 25(2):71-8

Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus.

Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS. 2015. Neurobiology of aging 36(3): 1600 e1601-1604.

Methylomic trajectories across human fetal brain development.

Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CC, O’Donovan MC, Bray NJ, Mill J. 2015. Genome research 25(3): 338-352.

DNA modification study of major depressive disorder: beyond locus-by-locus comparisons.

Oh G, Wang SC, Pal M, Chen ZF, Khare T, Tochigi M, Ng C, Yang YA, Kwan A, Kaminsky ZA et al. 2015. Biol Psychiatry 77(3): 246-255.

Intermediate DNA methylation is a conserved signature of genome regulation.

Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M et al. 2015. Nature communications 6: 6363.

Alzheimer’s disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C et al. 2014. Nature neuroscience 17(9): 1156-1163.

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer’s disease.

Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R et al. 2014. Nature neuroscience 17(9): 1164-1170.

Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study.

Cecil CA, Lysenko LJ, Jaffee SR, Pingault JB, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED. 2014. Mol Psychiatry 19(10): 1071-1077.

Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer’s disease.

Sassi C, Guerreiro R, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C et al. 2014. Neurobiology of aging 35(10): 2422 e2413-2426.

Plasma proteins predict conversion to dementia from prodromal disease.

Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M et al. 2014.  Alzheimer’s & dementia : the journal of the Alzheimer’s Association 10(6): 799-807 e792.

Epigenetics in health and disease: heralding the EWAS era.

Murphy TM, Mill J. 2014. Lancet 383(9933): 1952-1954.

Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.

Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S et al. 2014. Mol Psychiatry 19(1): 88-98.

Genetic differences in cytochrome P450 enzymes and antidepressant treatment response.

Hodgson K, Tansey K, Dernovsek MZ, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D et al. 2014. J Psychopharmacol 28(2): 133-141.

Alzheimer’s disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood.

Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H, Kloszewska I et al. 2014. Neurobiology of aging 35(2): 279-290.

Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression.

Dempster EL, Wong CC, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC. 2014. Biol Psychiatry 76(12): 977-983.

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer’s disease brain.

Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L et al. 2014. Neurobiology of aging 35(8): 1850-1854.

Epigenetically regulated microRNAs in Alzheimer’s disease.

Van den Hove DL, Kompotis K, Lardenoije R, Kenis G, Mill J, Steinbusch HW, Lesch KP, Fitzsimons CP, De Strooper B, Rutten BP. 2014. Neurobiology of aging 35(4): 731-745.

Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47,XXY) karyotype in the brain.

Viana J, Pidsley R, Troakes C, Spiers H, Wong CC, Al-Sarraj S, Craig I, Schalkwyk L, Mill J. 2014.  Epigenetics 9(4): 587-599.

Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits.

Wong CC, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J. 2014. Mol Psychiatry 19(4): 495-503.

Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain.

Basil P, Li Q, Dempster EL, Mill J, Sham PC, Wong CC, McAlonan GM. 2014.  Translational psychiatry 4: e434.

Differential methylation of the TRPA1 promoter in pain sensitivity.

Bell JT, Loomis AK, Butcher LM, Gao F, Zhang B, Hyde CL, Sun J, Wu H, Ward K, Harris J et al. 2014. Nature communications 5: 2978.

Hypermethylation in the ZBTB20 gene is associated with major depressive disorder.

Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai PC, Collier DA et al. 2014. Genome Biol 15(4): R56.

The mitochondrial epigenome: a role in Alzheimer’s disease?

Devall M, Mill J, Lunnon K. 2014. Epigenomics 6(6): 665-675.

Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease.

Fitzsimons CP, van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, van den Hurk M, Boks MP, Biojone C, Joca S et al. 2014.  Molecular neurodegeneration 9: 25.

Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats.

Ilott NE, Schneider T, Mill J, Schalkwyk L, Brolese G, Bizarro L, Stolerman IP, Dempster E, Asherson P. 2014. PLoS One 9(2): e88896.

Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.

Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ et al. 2014. Genome Biol 15(10): 483.

Analysis of HSPA8 and HSPA9 mRNA expression and promoter methylation in the brain and blood of Alzheimer’s disease patients.

Silva PN, Furuya TK, Braga IL, Rasmussen LT, Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payao SL et al. 2014.  Journal of Alzheimer’s disease : JAD 38(1): 165-170.

Transcriptomic changes in the frontal cortex associated with paternal age.

Smith RG, Fernandes C, Kember R, Schalkwyk LC, Buxbaum J, Reichenberg A, Mill J. 2014.  Mol Autism 5(1): 24.

Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins.

Ouellet-Morin I, Wong CC, Danese A, Pariante CM, Papadopoulos AS, Mill J, Arseneault L. 2013.  Psychol Med 43(9): 1813-1823.

Protection from genetic diathesis in attention-deficit/hyperactivity disorder: possible complementary roles of exercise.

Rommel AS, Halperin JM, Mill J, Asherson P, Kuntsi J. 2013. Journal of the American Academy of Child and Adolescent Psychiatry 52(9): 900-910.

Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys.

Barros M, Dempster EL, Illott N, Chabrawi S, Maior RS, Tomaz C, Silva MA, Huston JP, Mill J, Muller CP. 2013. Addict Biol 18(3): 452-454.

Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study.

Shalev I, Moffitt TE, Sugden K, Williams B, Houts RM, Danese A, Mill J, Arseneault L, Caspi A. 2013. Mol Psychiatry 18(5): 576-581.

Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease.

Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, Mill J. 2013. Mol Psychiatry 18(6): 635-636.

Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future.

Dempster E, Viana J, Pidsley R, Mill J. 2013. Schizophr Bull 39(1): 11-16.

Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients.

Murphy TM, Mullins N, Ryan M, Foster T, Kelly C, McClelland R, O’Grady J, Corcoran E, Brady J, Reilly M et al. 2013. Genes Brain Behav 12(1): 125-132.

Mining methylome databases.

O’Rourke CJ, Murphy TM, Hollywood D, Perry AS. 2013. Trends in genetics : TIG 29(2): 63-65.

Quantitative promoter DNA methylation analysis of four candidate genes in anorexia nervosa: a pilot study.

Pjetri E, Dempster E, Collier DA, Treasure J, Kas MJ, Mill J, Campbell IC, Schmidt U. 2013. Journal of psychiatric research 47(2): 280-282.

Epigenetic studies in Alzheimer’s disease: current findings, caveats, and considerations for future studies.

Lunnon K, Mill J. 2013.  Am J Med Genet B Neuropsychiatr Genet 162B(8): 789-799.

Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities.

Melas PA, Wei Y, Wong CC, Sjoholm LK, Aberg E, Mill J, Schalling M, Forsell Y, Lavebratt C. 2013.  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum 16(7): 1513-1528.

From promises to practical strategies in epigenetic epidemiology.

Mill J, Heijmans BT. 2013. Nature reviews Genetics 14(8): 585-594.

Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer.

Perry AS, O’Hurley G, Raheem OA, Brennan K, Wong S, O’Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L et al. 2013.  International journal of cancer Journal international du cancer 132(8): 1771-1780.

Inflammatory proteins in plasma are associated with severity of Alzheimer’s disease.

Leung R, Proitsi P, Simmons A, Lunnon K, Guntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I et al. 2013. PLoS One 8(6): e64971.

A blood gene expression marker of early Alzheimer’s disease.

Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H et al. 2013. Journal of Alzheimer’s disease : JAD 33(3): 737-753.

A data-driven approach to preprocessing Illumina 450K methylation array data.

Pidsley R, CC YW, Volta M, Lunnon K, Mill J, Schalkwyk LC. 2013.  BMC genomics 14: 293.

DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP.

Powell TR, Smith RG, Hackinger S, Schalkwyk LC, Uher R, McGuffin P, Mill J, Tansey KE. 2013.  Translational psychiatry 3: e300.

CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer’s disease patients.

Silva PN, Furuya TK, Sampaio Braga I, Rasmussen LT, de Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payao SL et al. 2013. Journal of Alzheimer’s disease : JAD 33(2): 349-355.

Stochastic choice of allelic expression in human neural stem cells.

Jeffries, A.R., Perfect, L.W., Ledderose, J., Schalkwyk, L.C., Bray, N.J., Mill, J., and Price, J. (2012).  Stem cells 30, 1938-1947.

IGFBP7 promoter methylation and gene expression analysis in prostate cancer.

Sullivan L, Murphy TM, Barrett C, Loftus B, Thornhill J, Lawler M, Hollywood D, Lynch T, Perry AS. 2012. The Journal of urology 188(4): 1354-1360.

CYP2C19 genotype predicts steady state escitalopram concentration in GENDEP.

Huezo-Diaz P, Perroud N, Spencer EP, Smith R, Sim S, Virding S, Uher R, Gunasinghe C, Gray J, Campbell D et al. 2012.  J Psychopharmacol 26(3): 398-407.

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood.

Davies, M., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R.A., Milosavljevic, A., Troakes, C., et al. (2012).  Genome Biol 13, R43.

Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse.

Kember, R.L., Dempster, E.L., Lee, T.H., Schalkwyk, L.C., Mill, J., and Fernandes, C. (2012).  Brain and behavior 2, 455-467.

Current status and future prospects for epigenetic psychopharmacology.

Boks MP, de Jong NM, Kas MJ, Vinkers CH, Fernandes C, Kahn RS, Mill J, Ophoff RA. 2012.  Epigenetics 7(1).

Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse.

Clarke TK, Dempster E, Docherty SJ, Desrivieres S, Lourdsamy A, Wodarz N, Ridinger M, Maier W, Rietschel M, Schumann G. 2012. Addict Biol 17(1): 202-208.

Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome.

Xie W, Barr CL, Kim A, Yue F, Lee AY, Eubanks J, Dempster EL, Ren B. 2012. Cell 148(4): 816-831.

Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight.

Pidsley R, Dempster E, Troakes C, Al-Sarraj S, Mill J. 2012a. Epigenetics 7(2): 155-163.

Commentary: The seven plagues of epigenetic epidemiology

Heijmans, B.T., and Mill, J. (2012). Int J Epidemiol 41, 74-78.

Epigenetic Studies of Schizophrenia: Progress, Predicaments, and Promises for the Future.

Dempster, E., Viana, J., Pidsley, R., and Mill, J. (2012). Schizophr Bull.

Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning.

Mizuno, K., Dempster, E., Mill, J., and Giese, K.P. (2012). Genes Brain Behav 11, 651-659.

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

Bell, J.T., Tsai, P.C., Yang, T.P., Pidsley, R., Nisbet, J., Glass, D., Mangino, M., Zhai, G., Zhang, F., Valdes, A., et al. (2012).  PLoS genetics 8, e1002629.

DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice.

Pidsley R, Fernandes C, Viana J, Paya-Cano JL, Liu L, Smith RG, Schalkwyk LC, Mill J. 2012. Mol Brain 5: 42.

Sleep quality and diurnal preference in a sample of young adults: associations with 5HTTLPR, PER3, and CLOCK 3111.

Barclay NL, Eley TC, Mill J, Wong CC, Zavos HM, Archer SN, Gregory AM. 2011. Am J Med Genet B Neuropsychiatr Genet 156B(6): 681-690.

Research Highlights: epigenetic changes to serotonin receptor gene expression in schizophrenia and bipolar disorder.

Pidsley, R., and Mill, J. (2011).  Epigenomics 3, 537-538.

Cytoarchitectural Disruption of the Superior Colliculus and an Enlarged Acoustic Startle Response in the Tuba1a Mutant Mouse.

Edwards A, Treiber CD, Breuss M, Pidsley R, Huang GJ, Cleak J, Oliver PL, Flint J, Keays DA. 2011. Neuroscience 195: 191-200.

Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys.

Barros, M., Dempster, E.L., Illott, N., Chabrawi, S., Maior, R.S., Tomaz, C., De Souza Silva, M.A., Huston, J.P., Mill, J., and Muller, C.P. (2011).  Addict Biol.

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer’s disease.

Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund LO, Kloszewska I et al. 2011. Mol Psychiatry 16(11): 1130-1138.

Drugs and addiction: an introduction to epigenetics.

Wong, C.C., Mill, J., and Fernandes, C. (2011).  Addiction 106, 480-489.

Transcriptomic analysis of autistic brain reveals convergent molecular pathology.

Voineagu, I., Wang, X., Johnston, P., Lowe, J.K., Tian, Y., Horvath, S., Mill, J., Cantor, R.M., Blencowe, B.J., and Geschwind, D.H. (2011). Nature 474, 380-384.

Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration.

Lunnon K, Teeling JL, Tutt AL, Cragg MS, Glennie MJ, Perry VH. 2011. J Immunol 186(12): 7215-7224.

A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder.

Kaminsky, Z., Tochigi, M., Jia, P., Pal, M., Mill, J., Kwan, A., Ioshikhes, I., Vincent, J.B., Kennedy, J.L., Strauss, J., et al. (2011).  Mol Psychiatry.

Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents.

Desrivieres S, Lourdusamy A, Muller C, Ducci F, Wong CP, Kaakinen M, Pouta A, Hartikainen AL, Isohanni M, Charoen P et al. 2011. Addict Biol 16(3): 510-513.

Toward an integrated genetic and epigenetic approach to Alzheimer’s disease.

Mill, J. (2011). Neurobiology of aging 32, 1188-1191.

Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research.

Pidsley, R., and Mill, J. (2011). Biol Psychiatry 69, 146-156.

In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer.

Murphy TM, Sullivan L, Lane C, O’Connor L, Barrett C, Hollywood D, Lynch T, Lawler M, Perry AS. 2011a. The Prostate 71(1): 1-17.

Eating disorders, gene-environment interactions and epigenetics.

Campbell, I.C., Mill, J., Uher, R., and Schmidt, U. (2011).  Neurosci Biobehav Rev 35, 784-793.

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder.

Dempster, E.L., Pidsley, R., Schalkwyk, L.C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011). Hum Mol Genet 20, 4786-4796.

Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.

Engmann, O., Hortobagyi, T., Pidsley, R., Troakes, C., Bernstein, H.G., Kreutz, M.R., Mill, J., Nikolic, M., and Giese, K.P. (2011).  Brain 134, 2408-2421.

Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness.

Ingason A, Kirov G, Giegling I, Hansen T, Isles AR, Jakobsen KD, Kristinsson KT, le Roux L, Gustafsson O, Craddock N et al. 2011.  Am J Psychiatry 168(4): 408-417.

Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project.

Keers R, Uher R, Huezo-Diaz P, Smith R, Jaffee S, Rietschel M, Henigsberg N, Kozel D, Mors O, Maier W et al. 2011. Pharmacogenomics J 11(2): 138-145.

Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms.

Murphy TM, Ryan M, Foster T, Kelly C, McClelland R, O’Grady J, Corcoran E, Brady J, Reilly M, Jeffers A et al. 2011b. Behav Brain Funct 7: 22.

Epigenetics and Chronic Diseases: An Overview.

Smith R, Mill J. 2011. In Epigenetic Aspects of Chronic Disease, Vol 1. Springer.

A longitudinal twin study of skewed X chromosome-inactivation.

Wong, C.C., Caspi, A., Williams, B., Houts, R., Craig, I.W., and Mill, J. (2011).  PLoS One 6, e17873.

Brain weight in males is correlated with DNA methylation at IGF2.

Pidsley, R., Dempster, E.L., and Mill, J. (2010).  Mol Psychiatry 15(9), 880-881.

Allele-specific methylation in the human genome: implications for genetic studies of complex disease.

Meaburn, E.L., Schalkwyk, L.C., and Mill, J. (2010). Epigenetics 5, 578-582.

Selected summaries from the XVII World Congress of Psychiatric Genetics, San Diego, California, USA, 4-8 November 2009.

Amstadter AB, Balachandar V, Bergen SE, Ceulemans S, Christensen JH, Cole J, Dagdan E, De Luca V, Ducci F, Tee SF et al. 2010. Psychiatr Genet 20(5): 229-268.

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus.

Bell, C.G., Finer, S., Lindgren, C.M., Wilson, G.A., Rakyan, V.K., Teschendorff, A.E., Akan, P., Stupka, E., Down, T.A., Prokopenko, I., et al. (2010). PLoS One 5.

DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA.

Docherty, S.J., Davis, O.S., Haworth, C.M., Plomin, R., and Mill, J. (2010).  Methods 52, 255-258.

Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies.

Lundstrom, S., Haworth, C.M., Carlstrom, E., Gillberg, C., Mill, J., Rastam, M., Hultman, C.M., Ronald, A., Anckarsater, H., Plomin, R., et al. (2010). J Child Psychol Psychiatry 51, 850-856.

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.

Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Guntert A et al. 2010. Arch Gen Psychiatry 67(7): 739-748.

No evidence of an association between two genes, EDN1 and ACE, and childhood-onset mood disorders.

Dempster EL, Kiss E, Kapornai K, Daroczi G, Mayer L, Baji I, Tamas Z, Gadoros J, Kennedy JL, Vetro A et al. 2010. Am J Med Genet B Neuropsychiatr Genet 153B(1): 341-346.

Allelic skewing of DNA methylation is widespread across the genome.

Schalkwyk, L.C., Meaburn, E.L., Smith, R., Dempster, E.L., Jeffries, A.R., Davies, M.N., Plomin, R., and Mill, J. (2010). Am J Hum Genet 86(2), 196-212.

Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease.

Asuni AA, Hilton K, Siskova Z, Lunnon K, Reynolds R, Perry VH, O’Connor V. 2010. Neuroscience 165(3): 662-674.

A longitudinal study of epigenetic variation in twins.

Wong, C.C., Caspi, A., Williams, B., Craig, I.W., Houts, R., Ambler, A., Moffitt, T.E., and Mill, J. (2010).  Epigenetics 5(6), 516-526.

No association between genetic markers in BDNF gene and lithium prophylaxis in a Greek sample.

Drago A, Serretti A, Smith R, Huezo-Diaz P, Malitas P, Albani D, Ronchi DD, Pae C-U, Aitchison KJ. 2010. International Journal of Psychiatry in Clinical Practice 14(2): 154-157.

The Role of Tuba1a in Adult Hippocampal Neurogenesis and the Formation of the Dentate Gyrus.

Keays DA, Cleak J, Huang GJ, Edwards A, Braun A, Treiber CD, Pidsley R, Flint J. 2010.  Developmental Neuroscience 32(4): 268-277.

Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD).

Mill J, Wigg K, Burcescu I, Vetro A, Kiss E, Kapornai K, Tamas Z, Baji I, Gadoros J, Kennedy JL et al. 2009. Am J Med Genet B Neuropsychiatr Genet 150B(6): 866-873.

The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis.

Dutt A, McDonald C, Dempster E, Prata D, Shaikh M, Williams I, Schulze K, Marshall N, Walshe M, Allin M et al. 2009. Psychol Med 39(11): 1783-1797.

Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project.

Perroud N, Aitchison KJ, Uher R, Smith R, Huezo-Diaz P, Marusic A, Maier W, Mors O, Placentino A, Henigsberg N et al. 2009. Neuropsychopharmacology 34(12): 2517-2528.

Epigenetic mediation of environmental influences in major psychotic disorders.

Rutten, B.P., and Mill, J. (2009).  Schizophr Bull 35(6), 1045-1056.

Moderation of antidepressant response by the serotonin transporter gene.

Huezo-Diaz P, Uher R, Smith R, Rietschel M, Henigsberg N, Marusic A, Mors O, Maier W, Hauser J, Souery D et al. 2009. Br J Psychiatry 195(1): 30-38.

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease.

Cunningham C, Campion S, Lunnon K, Murray CL, Woods JF, Deacon RM, Rawlins JN, Perry VH. 2009.  Biol Psychiatry 65(4): 304-312.

Genetic predictors of response to antidepressants in the GENDEP project.

Uher R, Huezo-Diaz P, Perroud N, Smith R, Rietschel M, Mors O, Hauser J, Maier W, Kozel D, Henigsberg N et al. 2009.  Pharmacogenomics J 9(4): 225-233.

Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation.

Docherty, S.J., Davis, O.S., Haworth, C.M., Plomin, R., and Mill, J. (2009).  Epigenetics Chromatin 2(1), 3.

The perceptions, views and opinions of university students about physics learning during undergraduate laboratory work.

Hanif M, Sneddon PH, Al-Ahmadi FM, Reid N. 2009. European Journal of Physics 30(1): 85.

Profiling DNA methylation from small amounts of genomic DNA starting material: efficient sodium bisulfite conversion and subsequent whole-genome amplification.

Mill J, Petronis A. 2009. Methods Mol Biol 507: 371-381.

Epigenetics, genomic mutations and cognitive function.

Reichenberg, A., Mill, J., and MacCabe, J.H. (2009).  Cogn Neuropsychiatry 14(4-5), 377-390.

Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model.

Smith, R.G., Kember, R.L., Mill, J., Fernandes, C., Schalkwyk, L.C., Buxbaum, J.D., and Reichenberg, A. (2009).  PLoS One 4(12), e8456.

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder.

Xu X, Mill J, Sun B, Chen CK, Huang YS, Wu YY, Asherson P. 2009. BMC Psychiatry 9: 3.

Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders.

Wong CC, Schumann G. 2008. Review. Philos Trans R Soc Lond B Biol Sci 363(1507): 3213-3222.

Association study of the estrogen receptor alpha gene (ESR1) and childhood-onset mood disorders.

Mill J, Kiss E, Baji I, Kapornai K, Daroczy G, Vetro A, Kennedy J, Kovacs M, Barr C. 2008a.  Am J Med Genet B Neuropsychiatr Genet 147B(7): 1323-1326.

Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility

Mill, J., and Petronis, A. (2008). . J Child Psychol Psychiatry 49(10), 1020-1030.

Epigenomic profiling reveals DNA-methylation changes associated with major psychosis.

Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008).  Am J Hum Genet 82(3), 696-711.

The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer.

Murphy TM, Perry AS, Lawler M. 2008. Endocrine-related cancer 15(1): 11-25.

Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth.

Brookes KJ, Neale B, Xu X, Thapar A, Gill M, Langley K, Hawi Z, Mill J, Taylor E, Franke B et al. 2008.  Am J Med Genet B Neuropsychiatr Genet 147B(1): 94-99.

Neuregulin-1 and the P300 waveform–a preliminary association study using a psychosis endophenotype.

Bramon E, Dempster E, Frangou S, Shaikh M, Walshe M, Filbey FM, McDonald C, Sham P, Collier DA, Murray R. 2008. Schizophr Res 103(1-3): 178-185.

Primary adrenal leiomyosarcoma: a case report and literature review.

M M, M B, M T, M V. 2008.  Clin Med Oncol 2: 353-356.

Molecular studies of major depressive disorder: the epigenetic perspective.

Mill, J., and Petronis, A. (2007).  Mol Psychiatry 12(9), 799-814.

Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders.

Dempster EL, Burcescu I, Wigg K, Kiss E, Baji I, Gadoros J, Tamas Z, Kennedy JL, Vetro A, Kovacs M et al. 2007a. Arch Gen Psychiatry 64(10): 1189-1195.

Rodent models: utility for candidate gene studies in human attention-deficit hyperactivity disorder (ADHD).

Mill J. 2007.  J Neurosci Methods 166(2): 294-305.

Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples.

Xu X, Mill J, Zhou K, Brookes K, Chen CK, Asherson P. 2007. Am J Med Genet B Neuropsychiatr Genet 144B(1): 83-86.

No evidence of association between a functional polymorphism in the MTHFR gene and childhood-onset mood disorders.

Dempster EL, Kiss E, Kapornai K, Daroczy G, Mayer L, Baji I, Tamas Z, Gadoros J, Kennedy JL, Vetro A et al. 2007b. Mol Psychiatry 12(12): 1063-1064.

Episodic memory performance predicted by the 2bp deletion in exon 6 of the “alpha 7-like” nicotinic receptor subunit gene.

Dempster EL, Toulopoulou T, McDonald C, Bramon E, Walshe M, Wickham H, Sham PC, Murray RM, Collier DA. 2006a. Am J Psychiatry 163(10): 1832-1834.

Whole genome amplification of sodium bisulfite-treated DNA allows the accurate estimate of methylated cytosine density in limited DNA resources.

Mill, J., Yazdanpanah, S., Guckel, E., Ziegler, S., Kaminsky, Z., and Petronis, A. (2006). Biotechniques 41(5): 603-607.

Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene.

Mill, J., Dempster, E., Caspi, A., Williams, B., Moffitt, T., and Craig, I. (2006).  Am J Med Genet B Neuropsychiatr Genet 141B(4): 421-425.

Is there an association between the COMT gene and P300 endophenotypes?

Bramon E, Dempster E, Frangou S, McDonald C, Schoenberg P, MacCabe JH, Walshe M, Sham P, Collier D, Murray RM. 2006. Eur Psychiatry 21(1): 70-73.

A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy.

Brookes KJ, Mill J, Guindalini C, Curran S, Xu X, Knight J, Chen CK, Huang YS, Sethna V, Taylor E et al. 2006. Arch Gen Psychiatry 63(1): 74-81.

Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.

Fernandes C, Hoyle E, Dempster E, Schalkwyk LC, Collier DA. 2006. Genes Brain Behav 5(6): 433-440.

Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts.

Mill J, Caspi A, Williams BS, Craig I, Taylor A, Polo-Tomas M, Berridge CW, Poulton R, Moffitt TE. 2006c. Arch Gen Psychiatry 63(4): 462-469.

The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.

Dempster, E.L., Mill, J., Craig, I.W., and Collier, D.A. (2006).  BMC Med Genet 7: 10.

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH. 2005. J Neurosci 25(40): 9275-9284.

Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples.

Xu X, Mill J, Chen CK, Brookes K, Taylor E, Asherson P. 2005a. Am J Med Genet B Neuropsychiatr Genet 139B(1): 11-13.

Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B.

Mill J, Xu X, Ronald A, Curran S, Price T, Knight J, Craig I, Sham P, Plomin R, Asherson P. 2005a.  Am J Med Genet B Neuropsychiatr Genet 133B(1): 68-73.

Association between BDNF val66 met genotype and episodic memory.

Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Filbey F, Wickham H, Sham PC, Murray RM, Collier DA. 2005.  Am J Med Genet B Neuropsychiatr Genet 134B(1): 73-75.

DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association.

Xu X, Knight J, Brookes K, Mill J, Sham P, Craig I, Taylor E, Asherson P. 2005b.  Am J Med Genet B Neuropsychiatr Genet 134B(1): 115-118.

Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1).

Mill J, Asherson P, Craig I, D’Souza UM. 2005b. BMC Genet 6: 3.

Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains.

Mill J, Sagvolden T, Asherson P. 2005c.  Behav Brain Funct 1: 24.

Functional effects of a tandem duplication polymorphism in the 5’flanking region of the DRD4 gene.

D’Souza UM, Russ C, Tahir E, Mill J, McGuffin P, Asherson PJ, Craig IW. 2004.  Biol Psychiatry 56(9): 691-697.

Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD.

Mill J, Curran S, Richards S, Taylor E, Asherson P. 2004a.  Am J Med Genet B Neuropsychiatr Genet 125B(1): 38-42.

Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes.

Lowe N, Kirley A, Hawi Z, Sham P, Wickham H, Kratochvil CJ, Smith SD, Lee SY, Levy F, Kent L et al. 2004. Am J Hum Genet 74(2): 348-356.

Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes.

Craig IW, Mill J, Craig GM, Loat C, Schalkwyk LC. 2004.  Eur J Hum Genet 12(8): 639-646.

Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD.

Mill J, Richards S, Knight J, Curran S, Taylor E, Asherson P. 2004b. Mol Psychiatry 9(8): 801-810.

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A et al. 2003. Science 301(5631): 386-389.

DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping.

Freeman B, Smith N, Curtis C, Huckett L, Mill J, Craig IW. 2003.  Behav Genet 33(1): 67-72.

Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder.

Mill J, Fisher N, Curran S, Richards S, Taylor E, Asherson P. 2003.  Neuroreport 14(11): 1463-1466.

The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample.

Chen CK, Chen SL, Mill J, Huang YS, Lin SK, Curran S, Purcell S, Sham P, Asherson P. 2003. Mol Psychiatry 8(4): 393-396.

Association of DRD4 in children with ADHD and comorbid conduct problems.

Holmes J, Payton A, Barrett J, Harrington R, McGuffin P, Owen M, Ollier W, Worthington J, Gill M, Kirley A et al. 2002. Am J Med Genet 114(2): 150-153.

Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR.

Mill J, Asherson P, Browes C, D’Souza U, Craig I. 2002a. Am J Med Genet 114(8): 975-979.

Role of genotype in the cycle of violence in maltreated children.

Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. 2002. Science 297(5582): 851-854.

Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity.

Mill J, Galsworthy MJ, Paya-Cano JL, Sluyter F, Schalkwyk LC, Plomin R, Asherson P. 2002b. Genes Brain Behav 1(3): 166-173.

Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder.

Mill J, Curran S, Kent L, Gould A, Huckett L, Richards S, Taylor E, Asherson P. 2002c.  Am J Med Genet 114(3): 269-271.

The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study.

Mill JS, Caspi A, McClay J, Sugden K, Purcell S, Asherson P, Craig I, McGuffin P, Braithwaite A, Poulton R et al. 2002d.  Mol Psychiatry 7(4): 383-391.

QTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptoms.

Curran S, Mill J, Sham P, Rijsdijk F, Marusic K, Taylor E, Asherson P. 2001a.  Am J Med Genet 105(4): 387-393.

Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples.

Curran S, Mill J, Tahir E, Kent L, Richards S, Gould A, Huckett L, Sharp J, Batten C, Fernando S et al. 2001b.  Mol Psychiatry 6(4): 425-428.

Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample.

Mill J, Curran S, Kent L, Richards S, Gould A, Virdee V, Huckett L, Sharp J, Batten C, Fernando S et al. 2001.  Mol Psychiatry 6(4): 440-444.

Rapid DNA extraction from ferns for PCR-based analyses.

Dempster EL, Pryor KV, Francis D, Young JE, Rogers HJ. 1999. Biotechniques 27(1): 66-68.