Entries by Jonathan Mill

Quantifying DNA hydroxymethylation in the human brain

A new paper from our group published in Genome Biology characterizes the distribution of DNA hydroxymethylation (5hmC) in two regions of the human brain. We used oxidative bisulfite (oxBS) treatment with the Illumina Infinium 450K BeadArray to quantify genome-wide patterns of 5hmC in the prefrontal cortex and cerebellum. Distinct patterns of 5hmC were identified in […]

Methylation QTLs (mQTLs) in the developing brain and their enrichment in schizophrenia-associated genomic regions

Our study looking at genetic influences on DNA methylation in the developing human brain was published online today in Nature Neuroscience. The study, led by Dr Eilis Hannon, identified >16,000 fetal brain mQTLs which were primarily cis-acting, enriched in regulatory chromatin domains and transcription factor binding sites, and showed substantial overlap with genetic variants that […]

ESRC and BBSRC grant for epigenetic research on early life experiences and long term health

Dr Chloe Wong has received funding and is the Principal Investigator for a project entitled ‘Epigenetic trajectories of biological response to adolescent psychosocial stress: A novel longitudinal study of discordant monozygotic twins.’ This is one of eight projects, funded by the ESRC and the BBSRC, which combines biological and social sciences to uncover the long […]