The Medical Research Council has funded us to continue our research into the genomic underpinnings of schizophrenia. The project will use cutting-edge methods to profile gene regulation (DNA modifications, histone modifications, gene expression, alternative splicing) in purified neuronal nuclei isolated from a unique collection of post-mortem brain samples.
Given the evidence for a neurodevelopmental component to the aetiology of schizophrenia, we will also annotate patterns of gene regulation across development of the human cortex, enabling us to explore the hypothesis that disease-associated loci are dynamically regulated during this critical period.
Building on our previous work exploring epigenomic variation in schizophrenia, our integrated-genomics project will explore the dynamic regulation of gene function during human brain development and its relevance to the aetiology of schizophrenia.
We’ll be looking for a postdoc and technician to work on this exciting project – so please keep an eye on our jobs page or get in touch directly with Jonathan Mill if you’re interested in joining our team!