GW4 accelerator award: Harnessing CRISPR/Cas9 technology to develop new models of Alzheimer’s disease
In collaboration with Nick Allen at the University of Cardiff, Vasanta Subramanian at the University of Bath, and James Hodge and Caroline Relton at the University of Bristol we have been awarded a GW4 accelerator award to investigate the functional consequences of epigenetic changes previously identified in Alzheimer’s disease brain by our group. Together we will establish novel genetic and epigenetic editing techniques and investigate the function of the ANK1 gene in Drosophila and human cellular models. GW4 is an alliance which combines the intellectual capacity and physical resources of the four leading research-intensive universities in the South West of England and Wales: Bath, Bristol, Cardiff and Exeter.